During the 1850s and 1860s Weston was a stop on a stage line from Sherman to Dallas.
On January 25, 1855, twenty-two acres & 35 poles were donated by Richard M & Catherine Mugg, John & Margaret Choat, and William & Barbery Culwell to the town of Weston with 8 lots reserved for their own personal use.
On February 26, 1857, the Town of Weston was officially located. Alexander T Robertson, John G Douglas, and Leonidas Wilson, were the Trustees for the town.
On June 2, 1873, Texas Governor Edmund J. Davis signed House Bill 901, incorporating the towns of Farmersville, Plano, and Weston. William Denny was Weston’s first mayor.
By 1890 the town had five general stores, a cotton gin, a gristmill, a confectioner, a shoemaker, a harness maker, three grocers, a druggist, a blacksmith, two churches, and a school. The population was estimated at 150.
By 1896 the population had risen to 400. The 1900 census reported the population of Weston as 316. It remained steady until 1968, when it was estimated at 216. In 1978 it was 209, and in 1980 it was 405. In 1990, 362 people lived in Weston. The population reached 635 in 2000. The population decline since 2000 resulted from voluntary and involuntary disannexations.